Core Center for Membrane Proteins (CCMP): Experts in complementary techniques to study membrane protein biology
A crystallization robot of the MPIBP consisting of three pipetting stations for screen development, crystallization plate setup, and liquid cubic phase (LCP) crystallisation plate setup, respectively, and six incubators sharing three imaging stations.
Mass spectrometry facility: The MPIBP is equipped with a nano-LC (Proxeon easy-nLC) and an analytical UPLC (Dionex Ultimate 3000 RSLC) coupled to a high-resolution ESI-q-TOF mass spectrometer (Bruker maXis) and a MALDI TOF/TOF mass spectrometer (Bruker Autoflex III Smartbeam).
Two powerful microfocus rotating anode X-ray generators at the MPIBP are equipped at one port with a CCD detector and very high flux optics, to be used in first preference for crystal screening, and at the second port equipped with high resolution optics and an image plate for precise data collection. Both screening stations will be equipped with automatic crystal mounting and centering robots.
Different kinds of equipment are provided to characterize proteins thermodynamically: A MicroCal capillary Differential Scanning Calorimeter (DSC) is available for determining the stability of investigated proteins. This is of particular relevance for membrane proteins, because their stability depends on the detergent used. An Isothermal Titration Calorimeter (ITC) can be used to study the binding of small molecules (such as lipids as well as substrates and inhibitors) to e.g. a membrane protein. Finally the MPIBP provides Differential Scanning Fluorimetry (DSF) as a quick method to determine the melting temperature of a protein. It requires only a small sample amount compared to other calorimetric methods and uses fluorimetric readout.
Cell-free (CF) protein expression: The IBPC has established new efficient protein sample production platforms based on CF expression technologies and implementing robotic throughput expression pipelines as well as large scale CF extract preparation facilities. A clear focus is on the production and structural characterization of integral membrane proteins.
By public transport: www.rmv.de transport maps (Schnellbahnplan)
From the Airport:
From the airport take the S-Bahn (S8 or S9 direction Hanau) to Frankfurt/Main and get off at Hauptwache (5 stops ~10 minutes), transfer to the U8 (direction Riedberg) and get off at UNI Campus Riedberg (14 stops) turn right and walk down to the Institute (~5 minutes).
Alternatively, take the U3 (direction Oberursel-Hohemark) and get off at Niederursel (13 stops). Turn right uphill following signs to the Universität (~10 minutes walk). The institute is ahead of you on the right of Max-von-Laue-Strasse.
Total: ~60-70 minutes.
By taxi: ~35 minutes, costs about 35-40 €
From the Main Station:
From Frankfurt Hbf Hauptbahnhof (lower level) take any S-Bahn S1 through S9 (directions Frankfurt-Süd, Offenbach, or Hanau), transfer at Hauptwache (2 stops) take the U8 (direction Riedberg) and get off at UNI Campus Riedberg (14 stops) turn right and walk down to the Institute (~5 minutes).
Alternatively, take the U3 (direction Oberursel-Hohemark) and get off at Niederursel (13 stops). Then walk ~10 minutes as above.
Total: ~40 minutes.
By taxi: ~20 minutes, costs about 25 €
By car:
From the South: (Frankfurter Kreuz)
→ A5 direction Kassel/Hannover, exit Nordwestkreuz Frankfurt
→ A66 direction Frankfurt-Miquelallee, exit Nordweststadt/Eschersheim, direction Oberursel/Nordweststadt
→ exit Universität/Mertonviertel (Marie-Curie-Straße). At the first traffic light turn left uphill, following signs to Universität/FIZ/Max-Planck-Institut. At the roundabout take the 3rd exit (Max-von-Laue-Strasse) and drive past the rust-coloured physics institute to the MPI on your left.
From the West: (Köln)
→ A3 exit Wiesbadener Kreuz
→ A66 direction Frankfurt-Miquelallee, exit Nordweststadt/Eschersheim, direction Oberursel/Nordweststadt, then follow directions above.
From the North: (Kassel)
→ A5 direction Basel, exit Bad Homburger Kreuz
→ A661 direction Frankfurt Ost/Offenbach
→ exit Heddernheim/Riedberg/Mertonviertel; turn right uphill at the second traffic light towards Universität/Max-Planck-Institut/FIZ, then follow directions above.
From the East: (Würzburg)
→ A3 direction Köln, exit Offenbacher Kreuz
→ A661 direction Frankfurt/Bad Homburg
→ exit Heddernheim/Riedberg/Mertonviertel, then follow directions above.
Parking: A small number of parking lots are available for temporary visitors next to the main entrance to the west of the building. Ask at the porter's lodge how to get access to the institute's main car park on the south of the building.
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