The Imaging Centre at EMBL Heidelberg gives access to state-of-the-art cryo-EM equipment for structure determination projects using the latest technology and methods in single-particle analysis, cryo-electron tomography (cryo-ET) and Cryo-correlative light and electron microscopy (Cryo-CLEM).
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login to contact The EMBL Heidelberg operates the Imaging Centre, a user facility providing cryo-EM services. EM engineers and application specialists will help and support any scientist with cryo-EM data collection to tackle a broad range of biological questions and projects based on single-particle analysis and cryo-electron tomography for high-resolution structural determination of macromolecular complexes. We also provide support on direct correlation between confocal fluorescence imaging and cellular tomography under cryo conditions (cryo-CLEM). The centre is also offering remote service to all interested users.
Currently we offer access to the following services:
1. High-end data collection for cryo-EM single-particle analysis
2. High-end data collection for cryo-electron tomography
3. Cryo-confocal imaging and cellular tomography under cryo conditions
Specific equipment:
Thermo Fisher Scientific Glacios equipped with a Falcon 4 electron counting direct electron detector;
Thermo Fisher Scientific Titan Krios with a Falcon 4 electron counting camera and volta phase plate;
LSM900 Airyscan2 equipped with an Linkam cryo stage and configured for high-resolution confocal imaging of fluorescent sample;
ZEISS Crossbeam 550 equipped to generate cryo-lamellae;
The centre and its instruments are available for the entire scientific Instruct-ERIC community.
For more details on instruments, methods, experts, how to apply, please visit our website.