Native Mass Spectrometry is the utilisation of soft ionisation methods and biological like sample conditions to allow a mass spectrum of a natively folded (i.e. not denatured) protein to be collected. Coupled with high resolution and highly sensitive detectors, this allows for: accurate mass, stoichiometry and, in some cases, small molecule/lipid binding partner determination.
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login to contact Native MS is highly-complementary to almost all the tools that are currently used in structural biology. From relatively small quantities of starting material, this technique can rapidly provide fundamental information to a structural biologist.