Structural mass spectrometry (MS3D) offers various methodologies for characterisation of protein structure. The Institute of Biotechnology/Centre of Molecular Structure (IBT/CMS) at BIOCEV offers different labelling approaches including hydrogen/deuterium exchange, covalent labelling, chemical cross-linking and limited proteolysis. The facility is equipped with cutting-edge technologies including high-resolution mass spectrometer, HPLC system, H/D system and in-house software for data processing.
The service provided includes data processing and reporting ready for publication. The platform also offers: identification and quantification of proteins, precise determination of protein molecular mass, and characterisation of various post translational modifications.
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login to contact Separation of protein mixtures
Intact protein analysis
Native mass spectrometry with ion mobility separation
Peptide/protein/metabolite profiling
Protein identification
Characterisation of protein modifications
Protein/metabolite quantification
Protein surface covalent labelling
Chemical cross-linking
Hydrogen/deuterium exchange (HDX)
Data processing and interpretation of mass spectrometric data
Shotgun proteomics
Hydrogen-deuterium exchange and covalent labelling experiments