Protein Production, Strasbourg, France

Sample preparation is not only a key issue for structural and molecular biology studies, but concerns life sciences development as a whole. Instruct centre France 1 offers state-of-the-art infrastructures for the expression and production of biomolecules and their complexes. The center proposes recombinant expression of protein and multi-protein complexes in prokaryotic and eukaryotic hosts as well as biomass production for isolation of poorly abundant proteins and endogenous complexes.

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Instruct Centre

Instruct Centre FR1

Service/Technology Contacts

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User Guide

Access to the platform allows users to perform small-scale tests to evaluate expression strategies and construct(s), and to produce samples at a larger scale for biochemical and structural investigations.

We offer different modes of access:

In general, the platform provides the expression vectors to the external users who perform cloning at their home institutions and come to IGBMC to perform expression assays and protein production. When this is not possible, cloning can be provided as a service
Given the highly experimental nature of the technology, variation to the access scheme can be discussed on a case-by case basis. In the case of projects that involve eukaryotic expression, based on baculovirus or mammalian expression, preliminary experiments are often performed by the platform and the user only comes to IGBMC for the scale up and training

Support includes training and supervision, as well as help with data analysis which is especially crucial for complex reconstitution. Users should not hesitate to contact us before submitting an application.