Solution NMR, CICbioGUNE, Bilbao, Spain

Flagship Service/Technology

The NMR Facility at the CiC bioGUNE institute for biosciences near Bilbao (Spain) enables a broad range of solution state NMR studies, with special focus on metabolomics and the analysis of molecular interactions, structures, and dynamics of proteins and glycans.

We primarily offer the acquisition of the broadest range of NMR spectra on customer provided samples, focusing on standard isotopes (1H, 2H, 13C, 15N, 19F, 31P)

Other services:

We furthermore offer assistance with:

• protein, glycan, or glycoprotein sample preparation for NMR, optionally with diverse stable isotope [2H, 13C, 15N] labeling patterns
• NMR methods implementation, optimisation, and development (to most flexibly adjust to customer needs)
• measurement of complete NMR data sets for more sophisticated studies, e.g. on molecular interactions (NMR titration series), dynamics (NMR relaxation measure-ments), conformational ensembles (NOESY and NMR relaxation measurements)
• analysis of acquired NMR spectra (e.g., signal assignment, analysis of molecular structure, dynamics, and interactions)
• molecular dynamics simulations (primarily to complement experimental data from diverse NMR relaxation measurements)
• NMR metabolics studies under calibrated SOPs (with or without subsequent statistical data analysis)
• broad NMR consulting (on all topics and services mentioned) internally or externally (at customer facility)
• remote implementation and supervision of NMR measurements (at customer facility)

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